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In his most famous experiment, Loewi took fluid from one frog heart and applied it to another, slowing the second heart and showing that synaptic signaling used chemical messengers. The Nobel Prize diploma of Otto Loewi, housed at the University of Graz
Otto Loewi was a German-born American physician and pharmacologist who, with Sir Henry Dale, received the Nobel Prize for Physiology or Medicine in 1936 for their discoveries relating to the chemical transmission of nerve impulses.
- The Editors of Encyclopaedia Britannica
May 27, 2021 · The paper reported an ingenious, yet straightforward experiment made by Professor Otto Loewi in 1920 and published in 1921, which constitutes the first clear-cut proof for the chemical nature of transmission of the nerve impulse from nerve to muscle.
- Ricardo Borges, Antonio G. García
- 2021
Oct 1, 2018 · October 1, 2018. Cellular neuroscience, History. Answer: Otto Loewi conducted experiments on frog hearts that demonstrated that a chemical was released by nerves that can influence heart rate. Otto Loewi (1873-1961) was a German pharmacologist.
From this experiment, Loewi hypothesized that electrical stimulation of the vagus nerve released a chemical into the fluid of chamber #1 that flowed into chamber #2. He called this chemical "Vagusstoff". We now know this chemical as the neurotransmitter called acetylcholine.
The foundation for Loewi's ideas. In the early 1900s, there was a great deal of discussion and experimentation designed to determine how communication across synapses occurred. In 1902, a young German researcher named Otto Loewi took a temporary position in a laboratory at University College London. There Loewi would meet several people who ...
The story of how Otto Loewi, then forty-eight years old, came up with the idea for his classic experiments on neurotransmitters has become folklore to researchers in the fields of pharmacology and neurophysiology.
