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Not recommended
- PCR-based testing (molecular testing) is not recommended for a primary diagnosis of Lyme disease because the organism is typically found in the peripheral circulation for a relatively brief period of time. 2 However, testing for B burgdorferi DNA may be useful under certain circumstances.
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Can PCR be used to diagnose Lyme disease?
What is the best test for Lyme disease?
How is Lyme disease diagnosed?
May 15, 2024 · Healthcare providers consider multiple factors when evaluating a patient for Lyme disease. Laboratory diagnosis of Lyme disease relies on a blood test that detects antibodies to the Lyme bacteria. It can take several weeks after infection for the immune system to make enough antibodies to be detected by the test.
PCR-based testing (molecular testing) is not recommended for a primary diagnosis of Lyme disease because the organism is typically found in the peripheral circulation for a relatively brief period of time. 2 However, testing for B burgdorferi DNA may be useful under certain circumstances.
- The First Test: Elisa
- The Second Test: Western Blot Or A Second Elisa
- A Possible Drawback of The Two-Step Testing System
This blood test is for antibodies against the Lyme disease bacteria. Because it can take some time for your body to produce antibodies, this test isn’t always accurate soon after a person is infected.
There are two options for the second test. One is called a Western blot, which looks at how your antibodies react to specific parts of the Lyme disease bacteria. The Western blot test has been part of the two-step testing system since 1994 and is more commonly used. The other option is to do a second ELISA test, which measures antibodies to a speci...
The CDC testing guidelines recommend a second test only if the first test is positive or unclear. Because the first test may not pick up antibodies soon after possible exposure to the Lyme disease bacteria, that means a person with Lyme disease may never get the second test. So, if your ELISA test is negative, you may want to ask your doctor to rep...
Yes. Reporting Name. Lyme Disease, PCR, Varies. Aliases. Borrelia afzelii. Borrelia burgdorferi by PCR. Borrelia burgdorferi sensu lato genogroup. Borrelia garinii. Borrelia mayonii. Lyme Disease (PCR) Lyme Disease, CSF. PCR. Sensu lato group. Spirochetes. Tick-Borne Diseases.
Nov 1, 2019 · Tests for Lyme disease can be divided into direct methods, which detect the spirochete itself by culture or by polymerase chain reaction (PCR), and indirect methods, which detect antibodies . Direct tests lack sensitivity for Lyme disease; hence, serologic tests remain the gold standard.
Diagnosis can be confirmed by serology blood tests which measure the antibodies that are formed by the immune system in response to the Lyme disease bacterial infection. Collection of cerebrospinal fluid by lumbar puncture may be indicated in neurologic cases that may involve the central nervous system.
