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- Here, we showed that Ssd significantly potentiated TNF- α -mediated cell death in HeLa and HepG2 cancer cells via suppression of TNF- α -induced NF- κ B activation and its target genes expression involving cancer cell proliferation, invasion, angiogenesis and survival.
Mar 12, 2013 · Upon binding of its cellular TNF- α receptor 1 (TNFR1), it induces apoptosis of cancer cells by either recruitment of TNFR-associated death domain (TRADD), and Fas-associated protein with death domain (FADD) [ 2, 3] or activation of reactive oxygen species (ROS) and cytochrome c release from mitochondria [ 4 ].
- Vincent Kam Wai Wong, Molly Miao Zhang, Hua Zhou, Kelly Yin Ching Lam, Po Ling Chan, Carmen Ka Man L...
- 10.1155/2013/745295
- 2013
- 2013
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Here, we showed that Ssd significantly potentiated TNF- α -mediated cell death in HeLa and HepG2 cancer cells via suppression of TNF- α -induced NF- κ B activation and its target genes expression involving cancer cell proliferation, invasion, angiogenesis and survival.
- Vincent Kam Wai Wong, Molly Miao Zhang, Hua Zhou, Kelly Yin Ching Lam, Po Ling Chan, Carmen Ka Man L...
- 2013
Oct 22, 2019 · Another report concluded that SSD enhances the anticancer potency of TNF-alpha by overcoming its undesirable response of activating NF-kappa B signaling in cancer cells 12. The results of these studies implied that SSD may be effective for overcoming multidrug resistance.
- Jian-Cai Tang, Feng Long, Jia Zhao, Jia Hang, Yong-Gang Ren, Jian-Ye Chen, Bo Mu
- 10.7150/jca.30361
- 2019
- J Cancer. 2019; 10(26): 6666-6672.
Oct 29, 2021 · Saikosaponin-D enhances the anticancer potency of TNF-α via overcoming its undesirable response of activating NF-Kappa B signalling in cancer cells. Evid Based Complement Alternat Med . 2013 :745295.
- Piao Zhou, Wei Shi, Xiao-Yan He, Quan-Yu Du, Fei Wang, Jing Guo
- 10.1080/13880209.2021.1992448
- 2021
- Pharm Biol. 2021; 59(1): 1478-1487.
Here, we showed that Ssd significantly potentiated TNF-α-mediated cell death in HeLa and HepG2 cancer cells via suppression of TNF-α-induced NF-κB activation and its target genes expression involving cancer cell proliferation, invasion, angiogenesis and survival.
tibacteria, antivirus and anticancer. Recently, we found that Ssd could inhibit the activated T lymphocytes via suppression of NF- B, NF-AT and AP-1 signaling. Here, we showed that Ssd significantly potentiated TNF- -mediated cell death in HeLa and HepG2 cancer c.
injection of recombinant TNF-𝛼into tumor-bearing mice [5–7]. Recently, TNF-𝛼is clinically used in the treatment of soft tissue sarcoma and melanomas with an acceptable
