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- After reading a report of Calmette's anti- Naja serum, Vital Brazil raised monovalent serum against the venom of Bothrops jararaca and the venom of Crotalus durissus terrificus.
www.sciencedirect.com › science › articlePioneers of anti-venomous serotherapy: Dr Vital Brazil (1865 ...
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May 1, 1992 · In 1898, Vital Brazil obtained clear evidence of a specificity of antivenins observing that serum from dogs immunized with B.jararaca venom was potent against that venom but did not neutralize that of C. d. terrificus just as the very potent serum against rattlesnake venom was quite weak in neutralizing the jararaca venom (BRAZIL, 1901b).
- On The Serum Therapeutics of Cases of Snake-Bite
The serum of a horse immunised with pure cobra venom is...
- Toxicon
Toxicon is affiliated with The Brazilian Society of...
- On The Serum Therapeutics of Cases of Snake-Bite
Vital Brazil estimated that, at the beginning of this century, deaths due to crotaline snakebites in the State of São Paulo, Brazil, were nearly 3000 per year, representing a mortality rate of about 25%, the majority being due to bothropic envenomation.
- Barbara J. Hawgood
- 1992
Aug 1, 2018 · In 1905, Vital definitively proved that the serum produced and shipped by Calmette did not protect against the venom of Brazilian snakes, confirming his discovery of antivenom specificity. He also reported the first case of the cure of an individual bitten by jararaca and treated with the specific serum.
- Carla Cristina Squaiella-Baptistão, Osvaldo Augusto Sant'Anna, José Roberto Marcelino, Denise V. Tam...
- 2018
Vital Brazil was convinced since his early work at Butantan that envenomations (poisoning by accidents with venomous animals, such as snakes, scorpions, spiders and batrachia, then the cause of thousands of deaths in Brazil) could be fought with antisera, i.e., antibodies specifically produced for venoms which were proteins or long-chain peptides.
May 1, 1992 · After reading a report of Calmette's anti- Naja serum, Vital Brazil raised monovalent serum against the venom of Bothrops jararaca and the venom of Crotalus durissus terrificus. In 1898 this led to the first demonstration of the specificity of anti-venomous serum and later, the first production of polyvalent serum for therapeutic use.
- Barbara J. Hawgood
- 1992
May 1, 2018 · Among his many achievements, Vital Brazil characterized the clinical features and toxicological profiles of the venoms of Brazilian snakes and prepared the first antivenoms of Latin America.
In his papers, Vital Brazil also demonstrated the specificity of the antiserum by showing that Calmette's anti-cobra serum was not effective against the venom of Brazilian Bothrops species, while antisera raised against venom of the Brazilian Bothrops jararaca as well as Crotalus durissus terrificus species proved to only be effective against ...
