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   What is a chassis in biology?

   • The chassis provides the energy to run the synthetic system and is often thought of as the ‘hardware’ of synthetic biology, and the bioparts and biological devices thought of as the ‘software’. The bioparts are ‘loaded and run’ in the chassis. Through modularisation of parts, the goal is ‘plug and play’ biology.

   Principles of synthetic biology - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8578974/

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   What is a chassis in synthetic biology?

   • In synthetic biology, the environment of the cell can be provided by an ‘off the shelf’ standard part – referred to as the chassis. The chassis provides the energy to run the synthetic system and is often thought of as the ‘hardware’ of synthetic biology, and the bioparts and biological devices thought of as the ‘software’.

   Principles of synthetic biology - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8578974/

   See all results for this question

   Why do cells need a chassis?

   • In particular, the cell is needed to provide energy to the biopart and to mediate inputs from outside the cell. In synthetic biology, the environment of the cell can be provided by an ‘off the shelf’ standard part – referred to as the chassis.

   Principles of synthetic biology - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8578974/

   See all results for this question

   Which bacterium is used as a chassis?

   • An alternative bacterium used as a chassis is Bacillus subtilis ( B. subtilis ). Thirdly, yeast, such as S. cerevisiae used in winemaking, brewing and baking, is a eukaryote, and therefore when used as a chassis it is more appropriate for thinking about our human cells.

   Principles of synthetic biology - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8578974/

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   Why do we need a new bacterial chassis?

   • New bacterial chassis are required to capitalize on the advanced functions and applications and expand the potential of SB further. Unfortunately, moving to new chassis bacteria is not as simple as porting the toolkits and circuits developed in E. coli into another bacterial species.

   The Next Generation of Synthetic Biology Chassis: Moving Synthetic Bio…

   pubs.acs.org/doi/10.1021/acssynbio.6b00256

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   What makes a CRISPR-Cas chassis a fieldable technology?

   • Furthermore, the CRISPR-Cas system has been investigated for one cyanobacteria species, (10) which is important for the development of this group as a chassis. Another key feature of a chassis for fieldable technology is the ability to withstand many extreme stresses.

   The Next Generation of Synthetic Biology Chassis: Moving Synthetic Bio…

   pubs.acs.org/doi/10.1021/acssynbio.6b00256

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2. standardsinsynbio.eu › what-is-a-chassis-inWhat is a chassis in Synthetic Biology? – Standardsinsybio

   standardsinsynbio.eu › what-is-a-chassis-in

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   Apr 30, 2021 · A chassis is defined as the load-bearing framework of an object. In other words, the chassis supports the weight and the structure of the object so that it can function correctly. To illustrate this concept, think of a car.

3. www.ncbi.nlm.nih.gov › pmc › articlesPrinciples of synthetic biology - PMC - National Center for ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 2, 2021 · In synthetic biology, the environment of the cell can be provided by an ‘off the shelf’ standard part – referred to as the chassis. The chassis provides the energy to run the synthetic system and is often thought of as the ‘hardware’ of synthetic biology, and the bioparts and biological devices thought of as the ‘software’.

   • Author: Kathryn L. Garner
   • DOI: 10.1042/EBC20200059

   • Publish Year: 2021
   • Publication: Essays Biochem. 2021 Nov; 65(5): 791-811.

4. www.youtube.com › watchWhat is a chassis? - YouTube

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   Oct 5, 2022 · What is a chassis organism, and how do you select the right one to use?Ma... Engineering genetic constructs into organisms is at the heart of synthetic biology.

5. pubmed.ncbi.nlm.nih.gov › 32889152For the sake of the Bioeconomy: define what a Synthetic ...

   pubmed.ncbi.nlm.nih.gov › 32889152

   Jan 25, 2021 · The concept of the chassis as a defined, reusable biological frame where non-native components can be plugged in and out to create new functionalities lies at the boundary between frontline bioengineering and more traditional recombinant DNA technology.

   • Author: Víctor de Lorenzo, Natalio Krasnogor, Markus Schmidt

   • Publish Year: 2021

6. pubs.acs.org › doi › 10The Next Generation of Synthetic Biology Chassis: Moving ...

   pubs.acs.org › doi › 10

   This viewpoint article focuses on the need for new SB chassis bacteria, particularly for use in biotechnology applications relevant to fieldable technologies, and highlights some potential organisms and toolkit development for the next generation SB chassis.

   • Author: Bryn L. Adams

   • Publish Year: 2016

7. www.ncbi.nlm.nih.gov › pmc › articlesEngineering and modification of microbial chassis for systems ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Dec 11, 2018 · In synthetic biology, a chassis refers to an organism that houses and supports genetic components by providing the resources that allow them to function [, , ]. Attempts to construct a synthetic microbial chassis can be classified into two complementary and alternative approaches: top down and bottom up.

8. www.ncbi.nlm.nih.gov › pmc › articlesProperties of alternative microbial hosts used in synthetic ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 11, 2016 · The chassis is the cellular host used as a recipient of engineered biological systems in synthetic biology. They are required to propagate the genetic information and to express the genes encoded in it.