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      • In SB, a chassis refers to the organism that serves as a foundation to physically house genetic components and supports them by providing the resources to function, such as transcription and translation machinery.
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  2. This viewpoint article underscores the need for new bacterial chassis, as well as discusses some of the important considerations in their selection. It also highlights a few examples of robust, tractable bacterial species that can meet the demands of tomorrow’s state-of-the-art in SB.

  3. Jan 25, 2021 · The notion of chassis marks the difference between GMOs and synthetic biology agents. Hosts of recombinant DNA may qualify as SynBio chassis if standard criteria are met. Genomic barcoding emerges as a must feature for tracing synthetic biology agents.

    • Víctor de Lorenzo, Natalio Krasnogor, Markus Schmidt
    • 2021
  4. Jan 25, 2021 · The concept of the chassis as a defined, reusable biological frame where non-native components can be plugged in and out to create new functionalities lies at the boundary between frontline bioengineering and more traditional recombinant DNA technology.

    • Víctor de Lorenzo, Natalio Krasnogor, Markus Schmidt
    • 2021
  5. Mar 1, 2019 · In synthetic biology, a chassis refers to an organism that houses and supports genetic components by providing the resources that allow them to function [ [8], [9], [10] ]. Attempts to construct a synthetic microbial chassis can be classified into two complementary and alternative approaches: top down and bottom up.

    • Haotian Chi, Haotian Chi, Xiaoli Wang, Yue Shao, Ying Qin, Zixin Deng, Lianrong Wang, Shi Chen, Shi ...
    • 2019
  6. Dec 11, 2018 · In synthetic biology, a chassis refers to an organism that houses and supports genetic components by providing the resources that allow them to function [ [8], [9], [10] ]. Attempts to construct a synthetic microbial chassis can be classified into two complementary and alternative approaches: top down and bottom up.

    • Haotian Chi, Haotian Chi, Xiaoli Wang, Yue Shao, Ying Qin, Zixin Deng, Lianrong Wang, Shi Chen, Shi ...
    • 10.1016/j.synbio.2018.12.001
    • 2019
    • Synth Syst Biotechnol. 2019 Mar; 4(1): 25-33.
  7. Nov 2, 2021 · The chassis provides the energy to run the synthetic system and is often thought of as the ‘hardware’ of synthetic biology, and the bioparts and biological devices thought of as the ‘software’.

  8. Aug 12, 2022 · We identify key challenges with using current model chassis and delineate major points of conflict in choosing the most suitable organisms as chassis for environmental biosensing. This framework provides a way forward in the selection of biosensor chassis for environmental synthetic biology.

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