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- Epidemiology of fever of unknown origin (FUO) varies based on etiology of fever, age group, geography, environmental exposure, and immune/HIV status. In developing countries, an infectious etiology of FUO is most prevalent whereas, in developed countries, FUO is likely due to non-infectious inflammatory disease.
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Sep 16, 2016 · Pyrexia of unknown origin (PUO), also known as fever of unknown origin (FUO), is a grouping of many unrelated medical conditions that share the feature of persistent unexplained fever despite basic investigation.
- Robyn W Beresford, Iain B Gosbell, Iain B Gosbell
- 2016
When investigating a patient with pyrexia of unknown origin (PUO), consider possible aetiologies in each of the following four broad categories: infective, inflammatory, neoplastic and miscellaneous. Address each in turn. Pyrexia of unknown origin is a diagnostic challenge and early involvement of specialists is important.
- Cristina Fernandez, Nicholas Beeching
- 10.7861/clinmedicine.18-2-170
- 2018
- Clin Med (Lond). 2018 Apr; 18(2): 170-174.
Sep 28, 2021 · Pyrexia or fever of unknown origin is defined as prolonged fever in an immunocompetent patient that has an unknown cause despite standard investigations. Infections, non-infectious inflammatory diseases, malignancy and other diseases can all cause pyrexia of unknown origin.
- Catharina M. Mulders-Manders, Catharina M. Mulders-Manders, Rishi Raj Banerjee, Rishi Raj Banerjee
- 2021
Oct 15, 2010 · Classic adult pyrexia of unknown origin is fever of 38.3°C or greater for at least 3 weeks with no identified cause after three days of hospital evaluation or three outpatient visits. Common causes are infections, neoplasms, and connective tissue disorders.
- George M Varghese, Paul Trowbridge, Tom Doherty
- 2010
Sep 16, 2016 · Pyrexia of unknown origin (PUO) is a syndrome that has long tested the skills of physicians to achieve a diagnosis in affected patients. By definition, patients included in this syndrome will be more difficult to diagnose as they have already resisted classification during baseline investigations.
- Robyn W Beresford, Iain B Gosbell, Iain B Gosbell
- 2016
In this article we review the possible aetiologies of PUO and present a systematic clinical approach to investigation and management of patients, recommending potential second-line investigations when the aetiology is unclear. Keywords: diagnosis; fever; fever of unknown origin; pyrexia; pyrexia of unknown origin.
In addition to PUO, inflammation of unknown origin (IUO) has been described as a clinical syndrome, in which a prolonged inflammatory clinical course is observed without continuous or intermittent fever. There is a significant overlap between PUO and IUO in terms of aetiology, management and utility of.
