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Mar 10, 2022 · Chagas disease can be treated with benznidazole (commercially available since May 14, 2018) or nifurtimox (2). Before January 25, 2021, nifurtimox (Lampit) had been exclusively available through CDC under an Institutional Review Board–approved Investigational New Drug (IND) treatment protocol, at which time it became reasonably accessible to ...
Apr 6, 2021 · Only two drugs, nifurtimox and benznidazole, are currently known to be effective against Trypanosoma cruzi, the protozoan which causes Chagas disease. Both drugs were developed decades ago, involve long treatment durations of 60 days or more, and have frequent side effects, especially in adults.
Nov 12, 2020 · Treatment for Chagas disease focuses on killing the parasite and managing signs and symptoms. During the acute phase of Chagas disease, the prescription medications benznidazole and nifurtimox (Lampit) may be of benefit. Both drugs are available in the regions most affected by Chagas disease.
Nov 21, 2019 · On average, patients receiving nifurtimox suffered more events (6.2 versus 3.5, P<0.001) than those in the benznidazole group and were more at risk of suffering five or more adverse events (69% versus 35.9%, P<0.001).
Nifurtimox, developed by Bayer, is a nitrofuran antiprotozoal drug used in the treatment of Chagas disease. On August 6 2020, accelerated FDA approval was granted for its use in pediatric patients in response to promising results from phase III clinical trials.
Aug 23, 2022 · The only drugs with proven efficacy against Chagas disease in human trials are benznidazole and nifurtimox [ 2-4 ]. In general, benznidazole is better tolerated and so is favored by most experts as the first-line treatment for Chagas disease [ 5 ].
Aug 23, 2023 · Benznidazole is an antibiotic that is used to treat Chagas disease in children ages 2 through 12 years. Chagas disease (also called American trypanosomiasis) is an infection caused by a parasite common to the areas of South America, Central America and Mexico.
