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Jan 12, 2011 · Mechanism of Action Nitroglycerin forms free radical nitric oxide (NO) which activates guanylate cyclase, resulting in an increase of guanosine 3'5' monophosphate (cyclic GMP) in smooth muscle and other tissues. These events lead to dephosphorylation of myosin light chains, which regulate the contractile state in smooth muscle, and result in ...
Feb 17, 2020 · Mechanism of Action. Nitroglycerin and other nitrates form free radical nitric oxide. In smooth muscle, nitric oxide activates guanylate cyclase which increases guanosine 3’5’ monophosphate (cGMP) leading to dephosphorylation of myosin light chains and smooth muscle relaxation. Produces a vasodilator effect on the peripheral veins and ...
Feb 29, 2024 · Metoprolol, a widely employed β-adrenergic antagonist, is pivotal in cardiovascular pharmacology. Metoprolol is indicated primarily for conditions such as hypertension, angina pectoris, heart failure, and arrhythmias. The medication exerts its therapeutic effect by selectively inhibiting β-1 adrenergic receptors, resulting in diminished cardiac contractility, heart rate, and blood pressure ...
Nov 10, 2022 · RECTIV (nitroglycerin) Ointment 0.4% contains 0.4% nitroglycerin w/w (4 mg nitroglycerin/1 g ointment), propylene glycol, lanolin, sorbitan sesquioleate, paraffin wax, and white petrolatum. RECTIV (nitroglycerin) Ointment 0.4% is available in tubes with a one-inch dosing line on the carton allowing the measurement of approximately 375 mg of ...
Sep 27, 2023 · Nitroglycerin sublingual tablets are indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease. 2 DOSAGE AND ADMINISTRATION. Administer one tablet under the tongue or in the buccal pouch at the first sign of an acute anginal attack. Allow tablet to dissolve without swallowing.
Jun 26, 2023 · ACE inhibitors are a medication class used to treat and manage hypertension, a significant risk factor for coronary disease, heart failure, stroke, and a number of other cardiovascular conditions. Most cases are primary and not attributable to any specific etiology. This activity reviews the indications, contraindications, mechanism of action, adverse events, and other key elements of ACE ...
Jul 10, 2023 · Meperidine is in the class of phenylpiperidine as a hydrochloride salt synthetic form of the opioid. Meperidine is used for the treatment of moderate to severe pain. It has intramuscular, subcutaneous, intravenous injection, syrup, and tablet forms. In the 20th century, it was the drug of choice among the opioids in the management of acute pain and the management of some patients with chronic ...
