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How the Dengue Virus Tricks the Immune System. Figure 1: Dengue viral infection. (A) A person is infected with the dengue virus when an infected mosquito bites the person’s skin. (B) The dengue ...
Dec 8, 2010 · Abstract. Antibody-dependent enhancement (ADE) has been proposed as a mechanism to explain dengue hemorrhagic fever (DHF) in the course of a secondary dengue infection. Very recently, Dejnirattisai et al., 2010 [ 1 ], published an important article supporting the involvement of anti-prM antibodies in the ADE phenomenon.
Feb 17, 2022 · Abstract. Dengue virus is an important human pathogen threating people, especially in tropical and sub-tropical regions. The viral genome has one open reading frame and encodes one polyprotein which can be processed into structural and nonstructural (NS) proteins. Four of the seven nonstructural proteins, NS2A, NS2B, NS4A and NS4B, are membrane ...
Mar 4, 2019 · In this study, we obtained five DENV1 isolates (DENV1 A to E) from the outbreak of dengue fever in 2014 of Guangzhou, China, and analyzed their replication efficiency and virulence in vitro and in vivo. The results suggested that among the five DENV1 strains, DENV1 B has the highest replication efficiency in both human and mosquito cells in ...
Mar 6, 2024 · Dengue is a mosquito-transmitted virus and is the leading cause of arthropod-borne viral disease worldwide, posing a significant global health concern. This disease is also known by various monikers, such as breakbone or 7-day fever, and is characterized by intense muscle spasms, joint pain, and high fever, reflecting both the severity and the duration of symptoms. Although most dengue fever ...
Feb 23, 2022 · In recent decades, the incidence of AKI associated with dengue virus infection has increased significantly 10 . Severe dengue affects about 6.0 to 6.7% of patients diagnosed with dengue 17 18 . Among hospitalized patients with severe dengue 3.3% to 4.8% develop AKI, of which 14.1% require dialysis 17 19 24 .
Nov 24, 2020 · The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility. NS1 protein and anti-DENV NS1 antibodies were believed to be ...
