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Dengue is an acute viral illness caused by RNA virus of the family Flaviviridae and spread by Aedes mosquitoes. Presenting features may range from asymptomatic fever to dreaded complications such as hemorrhagic fever and shock. A cute-onset high fever, muscle and joint pain, myalgia, cutaneous rash, hemorrhagic episodes, and circulatory shock ...
Oct 5, 2022 · Dengue (DENG-gey) fever is a mosquito-borne illness that occurs in tropical and subtropical areas of the world. Mild dengue fever causes a high fever and flu-like symptoms. The severe form of dengue fever, also called dengue hemorrhagic fever, can cause serious bleeding, a sudden drop in blood pressure (shock) and death.
Dengue is caused by a type of flavivírus, which is an enveloped virus of spherical geometry. Nowadays, it is one of the diseases with the highest incidence in Brazil, reaching the population of all states, regardless of social class. Several papers address the molecular aspects of infection of human cell by the viruses, which are reviewed in ...
Aug 1, 2017 · Natural killer (NK) cells play a protective role against dengue virus (DENV) infection, but the cellular and molecular mechanisms are not fully understood. Using an optimized humanized mouse model, we show that human NK cells, through the secretion of gamma interferon (IFN-γ), are critical in the early defense against DENV infection.
Jul 20, 2023 · Osawa et al. present cryoelectron microscopy analyses of protein-RNA complexes involved in the dengue virus RNA replication. These structures shed light on several key molecular mechanisms of flavivirus genome replication: promoter-dependent replication initiation, processive RNA elongation, and 5′ capping of the nascent genomic RNA.
Dec 15, 2023 · Dengue virus (DENV) disease is the most common arbovirus disease in the world. The incidence rate is increasing yearly, bringing a significant economic burden and medical pressure to the world. Dengue viral infection induces a series of clinical symptoms, among which dengue hemorrhagic fever and dengue shock syndrome are the most serious, and ...
May 1, 2024 · Therefore, although ADE is important in dengue disease pathogenesis, its specificity and functionality of DENV-specific antibodies appear to play a role. In ADE, poorly neutralizing and highly crossreactive antibodies enhance infection in FcγR-expressing cells, thereby increasing the intracellular viral loads (Figure 1) [42., 43., 44.].
