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Aug 1, 2017 · Dengue virus (DENV) infection is the most important arthropod-borne human viral disease worldwide. An estimated 390 million infections occur each year, of which 500,000 cases develop severe dengue and 20,000 die . DENV is a single-stranded RNA virus with four serotypes (DENV-1 to -4).
Oct 22, 2013 · Dengue is the most common arthropod-borne viral infection in humans with ∼50 million cases annually worldwide. In recent decades, a steady increase in the number of severe dengue cases has been ...
Nov 24, 2020 · The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility. NS1 protein and anti-DENV NS1 antibodies were believed to be ...
Jan 17, 2018 · The capsid protein of dengue virus is least conserved among related flavivirus and there is very limited information on the role of cytosolic proteins that interact with dengue virus capsid. We identified DEAD (Asp-Glu-Ala-Asp) Box Helicase 3, an X-Linked (DDX3X), cytosolic ATP-dependent RNA helicase as a dengue virus capsid-interacting protein.
Feb 23, 2022 · In recent decades, the incidence of AKI associated with dengue virus infection has increased significantly 10 . Severe dengue affects about 6.0 to 6.7% of patients diagnosed with dengue 17 18 . Among hospitalized patients with severe dengue 3.3% to 4.8% develop AKI, of which 14.1% require dialysis 17 19 24 .
Aug 1, 2017 · Dengue virus (DENV) infection is the most important arthropod-borne human viral disease worldwide. An estimated 390 million infections occur each year, of which 500,000 cases develop severe dengue and 20,000 die . DENV is a single-stranded RNA virus with four serotypes (DENV-1 to -4).
Sep 16, 2022 · The adaptive immune system is made up of the humoral immune response (mediated by B cells and neutralizing antibodies) and the cell-mediated immune response (mediated by CD4 + and CD8 + T cells). Both arms of the adaptive immune system play important roles in DENV disease pathogenesis ( Figure 3 ) ( Ye et al., 2013 ).
