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  1. Overview. Scleroderma is an uncommon, complex, autoimmune disease. The body's immune system attacks its own tissues. It affects the skin by causing hardened tissue or ulcers and may harm the internal organs. Doctors have made progress developing treatments to reduce symptoms and prolong life, but there is no cure.

  2. May 9, 2024 · Skin reactions such as pain, itching, burning, redness, dryness, peeling, crusting, swelling, blisters, and ulcers (see below) Tiredness. Fever. Headache. Flu-like symptoms (see below) Nausea ...

  3. Jun 8, 2012 · Scleroderma is a disease that causes the body's connective tissue and skin to harden and tighten. In some cases, only the skin is involved. But the disease can also damage other organs, including the kidneys, lungs, digestive tract and heart. The cause of scleroderma is unclear. Depending on the organs involved, medication may effectively slow ...

  4. Scleroderma is a rare, long-term (chronic) autoimmune disease that can affect the connective tissue in the skin, joints and internal organs. An autoimmune disease develops when the body’s immune system mistakenly attacks healthy tissue. In scleroderma, this leads to the overproduction of collagen, an important part of connective tissue.

  5. Both Raynaud’s and digital ulcers occur in scleroderma because of narrowed blood vessels. Blood vessels lose the ability to return to their normal size between attacks, which leads to a reduced supply of oxygen and nutrients to the skin. This can result in dry, cracked skin and the formation of small ulcers on the fingers or thumbs.

  6. The term “localized scleroderma” as a primary diagnosis refers to the fact that this group of conditions is “localized” to the skin, with no internal organ involvement. Subscribe and receive a weekly email with important information about scleroderma and the National Scleroderma Foundation

  7. Linear scleroderma is a form of localized scleroderma which frequently starts as a streak or line of hardened, waxy skin on an arm or leg or on the forehead. Sometimes it forms a long crease on the head or neck, referred to as en coup de sabre because it resembles a saber or sword wound. Linear scleroderma tends to involve deeper layers of the ...

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