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May 26, 2024 · As positive-sense RNA viruses, the genomes of flaviviruses serve as the template for all stages of the viral life cycle, including translation, replication, and infectious particle production. Yet, they encode just 10 proteins, suggesting that the structure and dynamics of the viral RNA itself helps shepherd the viral genome through these stages.
Oct 3, 2017 · West Nile Virus (WNV) can cause neurological disease and death in people. WNV is commonly found in Africa, Europe, the Middle East, North America and West Asia. WNV is maintained in nature in a cycle involving transmission between birds and mosquitoes. Humans, horses and other mammals can be infected. West Nile Virus (WNV) is a member of the ...
Importantly, the flavivirus life cycle is intimately associated to host cell lipids. Along this line, flaviviruses rearrange intracellular membranes from the endoplasmic-reticulum of the infected cells to develop adequate platforms for viral replication and particle biogenesis.
Jan 11, 2017 · Protein interactions during the flavivirus life cycle elucidated by MS-based proteomics. (A) Flavivirus particle composition. Flaviviridae particles are composed of a capsid/core (C) surrounded positive strand RNA genome and enveloped by a host derived lipid bilayer in which the viral transmembrane domain glycoproteins M/E1 and E/E2 are ...
Jul 3, 2021 · Flaviviruses are enveloped viruses that infect multiple hosts. Envelope proteins are the outermost proteins in the structure of flaviviruses and mediate viral infection. Studies indicate that flaviviruses mainly use envelope proteins to bind to cell attachment receptors and endocytic receptors for the entry step. Here, we present current findings regarding key envelope protein amino acids that ...
Apr 12, 2021 · Lipids are involved in almost all aspects of the flavivirus life cycle including entry, fusion, replication, assembly and virus crosstalk with the host cell immune response [139,140,141,142,143,144,145]. However, only limited studies provided clues to show that specific lipids may be involved in flavivirus replication organelles formation.
Illustrated here are the early, pre-replication events in the flavivirus life cycle. Virus particles bind to cells through specific receptors, internalized via clathrin-mediated endocytosis, and trafficked to endosomes, where the low pH induces viral Envelope (E) glycoprotein-mediated fusion of the viral envelope bounding endosomal membranes.
