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The lack of a suitable animal model, a proper mechanistic study in pathogenesis, and ADE are the main hindrances in vaccine development. This review summarizes the current knowledge on DENV epidemiology, biology, and disease aetiology in the context of prevention and protection from dengue virus disease.
The dengue virus is spread through a human-to-mosquito-to-human cycle of transmission, with the mosquito Aedes aegypti as the primary vector. These mosquitoes live near humans in tropical and ...
May 14, 2024 · Key points All four dengue viruses are spread to people primarily through the bite of an infected Aedes species mosquito. A dengue vaccine is recommended for U.S. territories and freely associated states. Protect yourself from dengue by avoiding mosquito bites.
Nov 21, 2022 · The pathogenesis of dengue infection is attributable to both host and viral factors, including nonstructural proteins, subgenomic RNA, genome variation, immune cells and its soluble factors, antibody-dependent enhancement, and the presence of cross-reactive T cells.
Aug 14, 2023 · Substantial gaps remain in the comprehensive understanding of the pathogenesis of dengue virus (DENV) infections. In large part, this limitation is related to the lack of a suitable animal model of disease [ 1 ]. Rhesus monkeys develop RNAemia and viremia similar in a pattern to humans after DENV challenge but do not develop clinical disease. Careful epidemiologic and experimental challenge ...
Nov 24, 2020 · The pathogenesis of dengue virus infection and severe dengue manifestations is very complex and not completely understood. The pathophysiological hallmark of DHF/DSS is plasma leakage and deranged hemostasis. Even after being aware of plasma leakage in dengue since the last five decades, the clear-cut mechanism of this manifestation stills remains obscure [ 13 ]. The statement that the human ...
