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Jan 13, 2023 · Alternatively, the synthesis of 1,2,4,5-tetrasubstituted imidazole derivatives 62 could be achieved through the condensation of benzyl 56, aldehydes 63 and anilines 64 in the presence of ammonium acetate under the solvent-free catalysis of Fe 3 O 4 @SiO 2 /bipyridinium nanocomposite (Fe 3 O 4 @SiO 2 /BNC) (Figure 25). The catalyst was reused ...
Nov 12, 2014 · Microwave-assisted synthesis and the SAR studies of modified 9-oxo-thia-zolo[5,4-f] quinazoline-2-carbonitriles allowed identification of new amidine and imidate derivatives as potent and dual CDK1/GSK-3 inhibitors. Combination of lead optimization and molecular modeling studies allowed a dual CDK1/GSK-3 inhibitor with submicromolar values .
Jan 1, 2015 · The synthesis ga ve pure, high yield, and the one and only i solated product. Keyword s: N - phenylbenzamide, 1,3 - dip henylthiourea, Imino alcohol - amide tau tomerism, Rearran gement intermed ...
May 25, 2020 · Other stoichiometric reduction methods of nitrocompounds employ Zn or hydrazine for achieving high selectivity with sensitive substituents or particular synthesis two-step one pot synthesis [1, 3]. Hydrogenation, however, is actually the most important and more used method of reduction in aromatic nitro-compounds [1, 4].
Jan 31, 2024 · a N- versus α-C−H allylic alkylation.b Allylic alkylation of alkyl amines through protecting group strategy.c α-C−H Functionalization of activated primary amines through carbonyl catalysis.d ...
Aniline (from Portuguese anil 'indigo shrub', and -ine indicating a derived substance) [6] is an organic compound with the formula C6H5NH2. Consisting of a phenyl group ( −C6H5) attached to an amino group ( −NH2 ), aniline is the simplest aromatic amine. It is an industrially significant commodity chemical, as well as a versatile starting ...
Feb 10, 2018 · 1. Introduction. Bruton tyrosine kinase (Btk) is a member of Tec family kinases including Tec, Itk, Txk and Bmx [[1], [2], [3], [4]].Btk is one of the most important drug target, since it broadly expresses in all hematopoietic cells except of plasma and T cells, and plays a critical role in B cell receptor (BCR) and Fcγ receptor (FcγR) signaling pathways, where it regulates the activation ...
