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Jul 16, 2013 · Introduction. Von Willebrand disease (VWD) is a common autosomal inherited bleeding disorder caused by quantitative or qualitative defects of von Willebrand factor (VWF), a multi-adhesive protein which binds platelets to exposed subendothelium and carries factor VIII (FVIII) in circulation. 1, 2 As a consequence, FVIII, the protein deficient in hemophilia A, may be variably reduced.
Oct 25, 2016 · Von Willebrand disease (VWD) is a hereditary bleeding disorder first described in 1926 by Erik von Willebrand . VWD is caused by deficiency of von Willebrand factor (VWF). VWF is a blood glycoprotein, which have dual function: it facilitates platelet adhesion and aggregation and also serves as the carrier of coagulation factor 8 (FVIII).
Reynen E, James P. Von Willebrand disease and pregnancy: a review of evidence and expert opinion. Semin Thromb Hemost . 2016;42(7):717-723. Stoof SC, van Steenbergen HW, Zwagemaker A, et al. Primary postpartum haemorrhage in women with von Willebrand disease or carriership of haemophilia despite specialised care: a retrospective survey.
The laboratory evaluation of this disease will typically show a decrease in plasma concentration of both VWF protein (von Willebrand factor antigen [VWF:Ag]) and factor VIII (FVIII). Qualitative functional assays of VWF function (von Willebrand factor ristocetin cofactor
Reference Interval. • von Willebrand factor (vWF) activity: 50% to 150%. • von Willebrand factor (vWF) antigen: 50% to 150%. • Factor VIII activity: 50% to 150%. Average vWF levels (both antigen and activity) tend to vary by blood type. 6 One study found the mean vWF levels by blood type to be as follows: 7. • Type O: 74.8%.
Mar 24, 2018 · Von Willebrand disease is the most common bleeding disorder in women. There are three major types—type 1 with low levels of Von Willebrand factor (VWF), type 2 with abnormal VWF, and type 3 with no detectible WVF. Laboratory testing consists of checking factor...
coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3) D68.0. ... (Near) complete absence of von Willebrand factor
