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  1. Aug 8, 2019 · There is increasing recognition that a validated consensus definition of neonatal sepsis is a critical step to improve identification and treatment of septic neonates and improve related outcomes ...

  2. Apr 20, 2021 · The Kaiser Permanente neonatal sepsis calculator can be used as an alternative to the framework outlined in recommendation 1.3.5 for babies born after 34+0 weeks of pregnancy who are being cared for in a neonatal unit, transitional care or postnatal ward. It should only be used if it is part of a prospective audit, which should record:

  3. Aug 1, 2021 · Efforts to develop an evidence-based approach to the evaluation and management of young febrile infants have spanned more than 4 decades. 1 In the 1970s, concerns arose about the emergence and rapid progression of group B Streptococcus (GBS) infection in neonates, whose clinical appearance and preliminary laboratory evaluations did not always reflect the presence of serious disease. 2 Such ...

  4. Nov 24, 2021 · Cardiovascular dysfunction is a common sequela of sepsis. This review aims to highlight the pathophysiological mechanisms involved in hemodynamic disturbance in neonatal sepsis, provide insights ...

  5. Nov 11, 2022 · Abstract. Neonatal late-onset sepsis (LOS) continues to threaten morbidity and mortality within the neonatal intensive care unit (NICU) and poses ongoing diagnostic and therapeutic challenges. Early recognition of clinical signs, rapid evaluation, and prompt initiation of treatment are critical to prevent life-threatening deterioration.

  6. Feb 24, 2024 · The definition of neonatal sepsis revolves around the presence of infection and the systemic response it elicits in the newborn. The American Academy of Pediatrics defines neonatal sepsis as a clinical syndrome characterized by signs and symptoms of infection accompanied by a positive blood culture or other microbiological evidence ( Shane et ...

  7. Oct 1, 2021 · Early-onset sepsis (EOS) is a significant cause of morbidity and mortality among newborn infants. The overall incidence of the disease in the US birth population is ∼1 case per 1000 live births but is ∼10-fold higher among infants born preterm. 1 For preterm infants at the lowest gestational ages (GAs), EOS-related mortality approaches 50%. 2 Because of this risk, ∼80% of very preterm ...

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