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Nov 24, 2020 · The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility. NS1 protein and anti-DENV NS1 antibodies were believed to be ...
Dengue is caused by the dengue virus (DENVs) infection and clinical manifestations include dengue fever (DF), dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS). Due to a lack of antiviral drugs and effective vaccines, several therapeutic and control strategies have been proposed. A systemic literature review was conducted according ...
Aug 18, 2016 · This Primer provides a general overview on dengue, covering epidemiology, control, disease mechanisms, diagnosis, treatment and research priorities. Infection with any one of the four dengue virus ...
Jan 17, 2018 · The capsid protein of dengue virus is least conserved among related flavivirus and there is very limited information on the role of cytosolic proteins that interact with dengue virus capsid. We identified DEAD (Asp-Glu-Ala-Asp) Box Helicase 3, an X-Linked (DDX3X), cytosolic ATP-dependent RNA helicase as a dengue virus capsid-interacting protein.
Oct 1, 2023 · Dengue virus is a single-strand positive-sense RNA genome consisting of 11 kb in length [9].The single predictable polyprotein is translated by the genome that is used by the virus-encoded protein into seven non-structural proteins and three structural proteins, which are defined as follows: Non-structural gene 1 (NS1) Nonstructural gene 2 A (NS2A) and Nonstructural gene 2B (NS2b) Non ...
Aug 6, 2011 · Dengue virus is an arthropod-borne virus transmitted by Aedes mosquitoes. Dengue virus causes fever and hemorrhagic disorders in humans and non-human primates. Direct interaction of the virus introduced by a mosquito bite with host receptor molecule (s) is crucial for virus propagation and the pathological progression of dengue diseases.
Aug 4, 2020 · 1. Introduction. Dengue virus represents four dissimilar serotypes (DENV1-4) which were classified as Flaviviridae family and Flavivirus genus [].DENV are transmitted to humans by the bite of infected Aedes mosquitoes, like most common vector Aedes aegypti or to a lesser extent Aedes albopictus [].
