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Glucocorticoid receptor. The glucocorticoid receptor ( GR or GCR) also known as NR3C1 ( nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response.
Glucocorticoid. Cấu trúc hóa học của cortisol ( hydrocortisone ), một glucocorticoid nội sinh, cũng như một loại thuốc cho cơ thể. Glucocorticoid là một loại corticosteroid, là một loại hormone steroid. Glucocorticoid là corticosteroid liên kết với thụ thể glucocorticoid. [1] Chúng có mặt ở hầu ...
Hydrocortisone is the name for the hormone cortisol when supplied as a medication. [14] Uses include conditions such as adrenocortical insufficiency, adrenogenital syndrome, high blood calcium, thyroiditis, rheumatoid arthritis, dermatitis, asthma, and COPD. [1] It is the treatment of choice for adrenocortical insufficiency. [15]
Topical glucocorticoids are used in the treatment of many skin conditions. They provide anti-inflammatory, antimitotic, and immune-system suppressing actions through various mechanisms. [1] Hydrocortisone cream is a type of topical glucocorticoid that is commonly found on the market.
Cortisol is a steroid hormone, in the glucocorticoid class of hormones and a stress hormone. When used as a medication, it is known as hydrocortisone . It is produced in many animals, mainly by the zona fasciculata of the adrenal cortex in the adrenal gland. [1]
Jul 4, 2019 · Discovery of Glucocorticoids and the Glucocorticoid Receptor. The first steps leading to the discovery of glucocorticoids (GCs) took place in the 19th century when the physician Thomas Addison described that patients suffering from (chronic) fatigue, muscular degeneration, weight loss, and a strange darkening of the skin could obtain beneficial effects from adrenal extracts ().
Binding of synthetic glucocorticoid dexamethasone to ligand-binding domain of receptor in cytoplasm. Specialty. Endocrinology. Generalized glucocorticoid resistance or Chrousos syndrome is a rare genetic disorder that can run in families or be sporadic. It is characterized by partial or generalized target-tissue insensitivity to glucocorticoids.
