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Sep 6, 2022 · Apoptosis. The term "apoptosis" was first coined by Kerr, Wyllie, and Currie in 1972 (Kerr et al. 1972), and subsequently we have a more comprehensive understanding (Luo et al. 1998; Elmore 2007; Yang et al. 2017): Apoptosis is a gene-regulated, energy-dependent, active, and programmed cell death process accompanied by contraction, pyknosis, and the formation of apoptotic bodies, which ...
Jul 27, 2023 · Intracellular iron accumulation and lipid peroxidation are two major biochemical events that induce ferroptosis (Fig. 1). Multiple organelles, including mitochondria, ER, Golgi apparatus, and lysosome, are involved in regulating iron metabolism and redox balance, suggesting that a dynamic signaling network controls and enforces ferroptosis.
Jan 4, 2024 · Apoptosis: Caspase-3/7-mediated cell death. Apoptosis is the first identified form of regulated cell death and is carried out by intracellular caspase-3 and caspase-7, which cleave diverse intracellular substrates, causing cell shrinkage, chromatin fragmentation, membrane blebbing, and breakdown into membrane-wrapped vesicles called apoptotic bodies.
Dec 18, 2023 · The machinery that mediates cell death was first characterized in Caenorhabditis elegans, and homologues of the C. elegans cell death effector proteins, which include caspases and BCL-2 proteins ...
Dec 16, 2015 · The process of cell death is the mechanism through which organisms eliminate useless cells. Hence, it is a normal process that maintains homeostasis. Cell removal can be effectuated by several pathways that involve complex and regulated molecular events specific to each type of cell death. Diverse studies have evidenced different types of cell death: apoptosis, autophagy, and necrosis. This ...
Jun 5, 2021 · Short Note on Apoptosis. Apoptosis (from Ancient Greek ἀπόπτωσις, apóptōsis, "falling off") is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin ...
Jan 1, 2022 · There is a time lag between those biochemical events that inevitably lead to cell death and the morphological manifestations of necrosis. With transmission electron microscopy, morphologic changes of irreversible cell injury are generally evident somewhat earlier than with light microscopy.
