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Two broad issues are addressed: (i) the extent to which the occurrence and anatomical site of agent-attributable cancer in humans may be correlated with the occurrence and, where relevant, organ site of tumours in animals treated with the same agent; and (ii) whether known mechanisms of action of the carcinogenic agents in question, considered ...
Since the inception of the International Agency for Research on Cancer (IARC) in the early 1970s, the IARC Monographs Programme has evaluated more than 1000 agents with respect to carcinogenic hazard; of these, up to and including Volume 119 of the IARC Monographs, 120 agents met the criteria for classification as carcinogenic to humans (Group 1).
In February, 2009, 36 scientists from 16 countries met at the International Agency for Research on Cancer (IARC) to reassess the carcinogenicity of the biological agents classified as “carcinogenic to humans” (Group 1) and to identify additional tumour sites and mechanisms of carcinogenesis (tables 1 and 2). These assessments will be published as part B of Volume 100 of the IARC Monographs.1
Jun 15, 2021 · Most pathogens (bacteria, viruses, fungi, and parasites) associated with human cancers are categorized as Group I human carcinogens by the International Agency for Research on Cancer, IARC. These pathogens cause carcinogenesis via three known mechanisms: persistent infection that cause inflammation and DNA damage, initiation of oncogene ...
Sep 26, 2022 · A carcinogen is any substance or agent that has the potential to cause cancer. Common carcinogens include alcohol, tobacco, processed meats, UV rays, radon, and asbestos. Some people may come into ...
Overview. Volume 100 of the IARC Monographs, A Review of Human Carcinogens, covers all agents previously classified by IARC as "carcinogenic to humans (Group 1)" and was developed by six separate Working Groups: Pharmaceuticals; Biological agents; Arsenic, Metals, Fibres, and Dusts; Radiation; Personal Habits and Indoor Combustions; Chemical ...
Over time, these fibers can accumulate and cause scarring and inflammation, which can affect breathing and lead to serious health problems . Asbestos has been classified as a known human carcinogen (a substance that causes cancer) by the U.S. Department of Health and Human Services (HHS), the U.S. Environmental Protection Agency (EPA), and the ...
