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Mar 3, 2016 · Adult skeletal muscle is a postmitotic tissue with an enormous capacity to regenerate upon injury. This is accomplished by resident stem cells, named satellite cells, which were identified more than 50 years ago. Since their discovery, many researchers have been concentrating efforts to answer questions about their origin and role in muscle ...
Oct 20, 2015 · Skeletal muscle satellite cells have been investigated using numerous in vitro and in vivo animal models to assess their role in muscle fiber maintenance, regeneration, and/or growth. However, in recent years, substantial effort has been made to translate these results from cell and animal work to the human model.
Oct 18, 2021 · Specifically, satellite cells suppress the expression of certain collagen types, and fibroblasts regulate the maturation of satellite cells . These findings are supported by a study in which the fibroblast pool was genetically reduced in mice, resulting in premature maturation of satellite cells [ 94 ].
Satellite glial cells are a type of glia found in the peripheral nervous system, specifically in sensory, [2] sympathetic, and parasympathetic ganglia. [3] They compose the thin cellular sheaths that surround the individual neurons in these ganglia. In a SGC, the cell body is denoted by the region containing the single, relatively large nucleus.
Skeletal muscle satellite cells are considered to play a crucial role in muscle fiber maintenance, repair and remodeling [1]. Satellite cells. Mononucleated cells “wedged” between the basement membrane and plasma membrane of the muscle fiber. Act as stem cells and are responsible for the further growth and development of skeletal muscles.
Jul 1, 2015 · Abstract. Skeletal muscles are essential for vital functions such as movement, postural support, breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic multinucleated fibers. The life-long maintenance of muscle tissue is mediated by satellite cells, lying in close proximity to the muscle fibers.
Aug 15, 2012 · Following their discovery in 1961, it was speculated that satellite cells were dormant myoblasts, held in reserve until required for skeletal muscle repair. Evidence for this accumulated over the years, until the link between satellite cells and the myoblasts that appear during muscle regeneration was finally established. Subsequently, it was demonstrated that, when grafted, satellite cells ...
