Search results
4 days ago · Cytochrome P450s (P450s), a superfamily of heme-containing enzymes, existed in animals, plants, and microorganisms. P450s can catalyze various regional and stereoselective oxidation reactions, which are widely used in natural product biosynthesis, drug metabolism, and biotechnology.
4 days ago · Abstract. Cytochrome P450 monooxygenases (CYPs) are valuable biocatalysts for the oxyfunctionalization of non-activated carbon-hydrogen bonds. Most CYPs rely on electron transport proteins as redox partners.
3 days ago · The TCAs are highly metabolised by the cytochrome P450 (CYP) hepatic enzymes. Drugs that inhibit cytochrome P450 (for example cimetidine, methylphenidate, fluoxetine, antipsychotics, and calcium channel blockers) may produce decreases in the TCAs' metabolism, leading to increases in their blood concentrations and accompanying toxicity. [33]
1 day ago · Bupropion is metabolized in the body by a variety of pathways. The oxidative pathways are by cytochrome P450 isoenzymes CYP2B6 leading to R,R - and S,S -hydroxybupropion and, to a lesser degree, CYP2C19 leading to 4'-hydroxybupropion.
1 day ago · A major metabolic catalyst involved is the cytochrome P450 enzyme known as 2D6, or CYP2D6. A significant portion of the population has a functional deficiency in this enzyme and are known as poor CYP2D6 metabolizers.
4 days ago · Steroids are primarily oxidized by cytochrome P450 oxidase enzymes, such as CYP3A4. These reactions introduce oxygen into the steroid ring, allowing the cholesterol to be broken up by other enzymes into bile acids. [80] These acids can then be eliminated by secretion from the liver in bile. [81]
4 days ago · Related Pathway. 00140 Steroid hormone biosynthesis. 00830 Retinol metabolism. 00902 Monoterpenoid biosynthesis. 00904 Diterpenoid biosynthesis; Including: Gibberellin biosynthesis. 00905 Brassinosteroid biosynthesis. 00950 Isoquinoline alkaloid biosynthesis. 00980 Metabolism of xenobiotics by cytochrome P450. 00982 Drug metabolism - cytochrome ...
