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5 days ago · An elevated PLR represents an imbalance between platelet and lymphocyte counts and suggests an enhanced host inflammatory response to more aggressive tumor biology or cancer therapy. Elevated platelets have been proven to promote the progression and metastatic potential of tumor cells through several biological pathways, including the secretion ...
1 day ago · A recent study led by investigators at MSK and published in Nature Medicine, included a comprehensive analysis of non relapse mortality after CAR T cell therapy in patients with lymphoma and multiple myeloma across multiple clinical trials and real-world studies. In this Q&A we discuss the study's key findings and a new tool for assessing infection risk prior to CAR T cell therapy.
5 days ago · Reid M. Ness, MD, associate professor of medicine in gastroenterology, hepatology, and nutrition at Vanderbilt University Medical Center, says that it is important to note one strong caveat about the screening tool. “This is a colon cancer detection test, but it is not useful for colon cancer prevention,” says Dr Ness.
1 day ago · PURPOSE Thrombocytopenia is a relatively common dose-limiting toxicity during peptide receptor radionuclide therapy (PRRT) in patients with NET. Although uncommon, some patients develop persistent cytopenia and eventually therapy-related myeloid neoplasm (t-MN), which has a dismal prognosis. As the indications for PRRT are expanding, it is important to investigate factors that may predict ...
4 days ago · Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and its incidence is expected to increase in the coming years [1, 2].The clear cell histotype (ccRCC) is the most represented, accounting for two-thirds of diagnoses, while the other cases are classified as non-clear cell RCC (nccRCC), an umbrella definition, which comprises many different histologies often endowed ...
1 day ago · The platelet/high-density lipoprotein ratio (PHR) has been identified as a significant indicator of inflammation and a hypercoagulable state, demonstrating a strong link with the severity of ...
1 day ago · The first of these was from 118 consecutive patients at the MD Anderson Cancer Center, of whom 80% were neutropenic, with an IE incidence of 1.7% (2/118). 8 The second of these was from 43 patients of whom 46% were neutropenic and with an IE incidence of 2.3% (1/43). 3 Comparatively, these studies had lower rates of neutropenia in their cancer ...
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