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21 hours ago · Within the pain signaling pathway itself, transduction, transmission, modulation, and perception are the core elements involved in the mechanisms of pain physiology. These components collectively constitute the pain pathway from the stimulus at the time of tissue injury to its final processing in the brain.
2 days ago · Definition: Acute pain is a sudden onset of discomfort typically lasting less than six months. It is a direct response to a specific injury or illness. Characteristics: Acute pain is sharp, intense, and usually has a clear cause. It can be accompanied by physical symptoms such as swelling, redness, and limited mobility.
1 day ago · Lou et al. identify a hyperactivity noradrenaline pathway from the locus coeruleus to the hindlimb primary somatosensory cortex involved in active-sleep-deprivation-induced pain sensitization. Chemogenetic manipulation strategies show that inhibition of this LCNA→S1HLGlu pathway alleviates ASD-induced pain sensitization.
1 day ago · Pain is usually transitory, lasting only until the noxious stimulus is removed or the underlying damage or pathology has healed. But some painful conditions, such as rheumatoid arthritis, peripheral neuropathy, cancer, and idiopathic pain, may persist for years.
1 day ago · Significance. The anterolateral system (ALS) is a major ascending pathway from the spinal cord that underlies perception of pain, itch, and skin temperature. It is therefore an important target for development of treatments for chronic pain. Our understanding of this system has been hampered by the considerable diversity of its constituent cells.
2 days ago · If you have ever experienced inflammation-related pain—for example, due to arthritis—you've felt cyclooxygenase at work. COX is known as a rate-limiting enzyme because it serves as the major pathway or key for the formation of these prostanoids.
4 days ago · Pain is an unpleasant sensory and emotional experience. Acute nociceptive pain is induced by noxious stimuli, and is often a result of an intense or potentially damaging stimulus.
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related to: pain pathwaysExplore How Sodium Channels Transmit Acute Pain Signals. See How Each Nav Subtype Is Expressed Throughout The Body.
