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5 days ago · Lolamicin was especially effective against ... the antibiotic also appeared to leave commensal bacteria alone, since many are gram-positive bacteria that don’t have the Lol complex that ...
2 days ago · Discovery is complicated by Gram-negative bacteria's complex membrane structures and efflux pumps. Developing a Gram-negative-only antibiotic that spares the microbiome calls for targeting an ...
1 day ago · Gram-negative bacteria are a particular group of bacteria that is resistant to antibiotics. When antimicrobial resistance develops, recovery for people with these infections can become more difficult.
5 days ago · By inhibiting this system, lolamicin selectively kills pathogenic bacteria without harming non-pathogenic ones. The team’s experiments showed that lolamicin is effective against 130 drug-resistant strains. In mouse models of acute pneumonia and sepsis, lolamicin demonstrated significant therapeutic effects.
1 day ago · Plectasin is naturally produced by the black cup fungus ( Pseudoplectania nigrella ). It is a ‘host defense peptide’ that protects the fungus against pathogenic gram-positive bacteria. To ...
3 days ago · The rise of antibiotic resistance and a dwindling antimicrobial pipeline have been recognized as emerging threats to public health. The ESKAPE pathogens — Enterococcus faecium, Staphylococcus ...
