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1 day ago · The hippocampus and striatum are both the sites for adult neurogenesis 43,44. Overall, we observed no co-expression of lncRNA-PCGs for the human hippocampal region.
5 days ago · Population-level analyses that link genetic variants, regulatory elements, and different molecular forms of expressed genes to regulatory networks at the cellular level, in both the developing brain and adult brain; Single-cell-level maps of the prefrontal cortex from individuals diagnosed with mental disorders and neurodevelopmental disorders
1 day ago · By Tanya Thakur, MBBS Alzheimer’s disease (AD) is one of the most devastating illnesses among older adults. The disease not only degrades memories but also affects one’s independence and takes a toll on family members. AD is a progressive neurodegenerative disorder caused by the accumulation of abnormal misfolded protein deposits in the brain, including beta-amyloid […]
4 days ago · Modulation of in vivo adult neurogenesis (AN) is an evolving concept in managing neurodegenerative diseases. CDRI-08, a bacoside-enriched fraction of Bacopa monnieri, has been demonstrated for its neuroprotective actions, but its effect on AN remains unexplored.
2 days ago · “Neurogenesis is important for forming new memories but also for forgetting memories. We think this happens because when new neurons integrate into neural circuits, new connections are forged and older connections are lost, disrupting the ability to recall memories,” explains Fujikawa.
5 days ago · It is demonstrated that structured firing sequences are present in spontaneous activity of human brain organoids and ex vivo neonatal brain slices from the murine somatosensory cortex and suggested that temporal sequences do not arise in an experience-dependent manner, but are rather constrained by an innate preconfigured architecture established during neurogenesis.
5 days ago · Aging is a complex and multifaceted process involving a variety of interrelated molecular mechanisms and cellular systems. Phenotypically, the biological aging process is accompanied by a gradual loss of cellular function and the systemic deterioration of multiple tissues, resulting in susceptibility to aging-related diseases. Emerging evidence suggests that aging is closely associated with ...
