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5 days ago · Among the various mechanisms responsible for desire and satisfaction, the accumbens nucleus (NAc), located bilaterally in the midbrain, plays a pivotal role in the dopamine-regulated behaviors associated with rewards [ 5 ].
5 days ago · The nucleus accumbens (NAc) shell (NAsh) in the brain, along with the interactions between N-methyl-D-aspartate receptor (NMDAR) and the dopamine D1 receptor (D1R), as well as their downstream ERK/CREB signalling pathway in the NAc, are integral in regulating reward-seeking behaviour.
5 days ago · Adenosine A2A receptors (A2AR) in the nucleus accumbens of the brain play an important role in regulating sleep and motivation, but until now, no drugs have been able to selectively modulate...
4 days ago · They found that youth with ADHD had heightened connectivity between structures deep in the brain involved in learning, movement, reward and emotion (caudate, putamen and nucleus accumbens seeds) and structures in the frontal area of the brain involved in attention and control of unwanted behaviors (superior temporal gyri, insula, inferior ...
4 days ago · Previously, we analyzed the possible mechanisms of functioning of a complex neural network in the central nervous system, schematically presented in Fig. 1, which consists of olfactory structures—the olfactory bulb (OB), the anterior olfactory nucleus (AON), the piriform cortex (PC), the olfactory tubercle (OT), which is part of the nucleus accumbens (NA), the ventral pallidum, as well as ...
5 days ago · Decoding the Brain. Neurodevelopmental conditions, such as autism, and mental illness, such as schizophrenia and bipolar disorder, are very common. However, the underlying mechanisms of these disorders remain poorly understood owing to the range of clinical manifestations and the size and complexity of the human brain.
5 days ago · In contrast, the neuronal experiments revealed two distinct clusters of b-cCRE similarity: Neurons from various cortical regions share high overlap in b-cCRE usage with one another, while neurons in subcortical regions, specifically those in the basal ganglia such as the putamen and nucleus accumbens, also showed high overlap.
