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5 days ago · Inhibition of notch signaling inhibits the proliferation of T-cell acute lymphoblastic leukemia in both cultured cells and a mouse model.
1 day ago · Translation (Protein Synthesis): Definition, Steps, Inhibition, and Application. Translation is the process by which the genetic code carried by messenger RNA (mRNA) is decoded to produce a specific sequence of amino acids in a polypeptide chain, which folds into a functional protein. This process occurs in the cytoplasm of both prokaryotic and ...
5 days ago · RNA interference ( RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression by double-stranded RNA, through translational or transcriptional repression. Historically, RNAi was known by other names, including co-suppression, post-transcriptional gene silencing (PTGS), and quelling.
3 days ago · First, to enable covalent bond formation, the target of interest must have a suitably reactive and mechanistically compatible nucleophile within an accessible distance of a functional protein binding site (e.g., 5–10 Å). Second, the observed cellular efficacy of a covalent inhibitor largely dependent on the rate of cellular degradation, and ...
5 days ago · Immune system, the complex group of defense responses found in humans and other advanced vertebrates that helps repel disease-causing entities. Immunity from disease is conferred by two cooperative defense systems: innate immunity and acquired immunity. Learn more about the immune system’s mechanisms and evolution.
Jun 19, 2024 · Antibiotics are substances that inhibit the growth of bacteria. They work by killing bacteria or preventing their reproduction, and may be synthesized chemically or by...
2 days ago · They can inhibit (silence) gene expression by binding to target mRNA and inhibiting translation, thereby preventing functional proteins from being produced. Many miRNAs play significant roles in cancer and other diseases.
