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22 hours ago · Researchers have uncovered how a structure in bodily carbohydrates (sugar chains or "glycans") that regulates how they attach themselves to other molecules interacts with key enzymes, and in so ...
2 days ago · Monte Carlo optimization through sampling of glycan degrees of freedom (DOFs) is carried out through the new GlycanSampler, which includes routines for glycosidic torsion angle (backbone) sampling, structure minimization, hydroxyl and other side-chain optimization, and neighbor protein side-chain optimization. During the protocol, the total ...
1 day ago · Unlike other glycan modification enzymes that require a separate transporter to transport substrates cross the ... ECD likely facilitates optimal binding of long-chain HS in the lumen with its CBM ...
22 hours ago · ENGASE, or endo-beta-N-acetylglucosaminidase, is an enzyme that hydrolyzes N-glycan chains from glycoproteins. This process involves the cleavage of the bond between the two N-acetylglucosamine (GlcNAc) residues in the core region of these carbohydrates.
Jun 27, 2024 · The conserved N-glycan on the IgG Fc domain greatly affects this binding affinity. The core-fucose residue of the heavy chain constant region (CH)-associated N-glycans plays a critical role in regulating antibody effector function in ADCC [2, 14,15,16,17,18,19,20].
5 days ago · To assess the potential impact of these glycans, we modeled a Man 9 GlcNac 2 chain at each site of glycosylation. This glycan was selected as our estimated molecular weight of sEGFRvIII suggests an ∼2,000 Da glycan chain at each site.
5 days ago · The UGT-catalyzed glycosylation of triterpenoids is commonly considered the final stage in the biosynthesis of triterpenoid saponins; it plays a crucial role in generating diversity and biological activity. A typical triterpenoid saponin contains 2 to 5 glycans, which usually form a sugar chain at the C-3 and/or C-28 position of the saponin.
