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3 days ago · Guides were then screened in vitro in a ‘cell-free detection assay’ (Fig. 2b–d).LbuCas13a 9,10,12,13 protein, a guide, target and reporter RNA (dual-fluorophore-quencher labelled polyU ...
3 days ago · WHO 2009 Dengue Classification. Dengue is defined by a combination of ≥2 clinical findings in a febrile person who lives in or traveled to (in the last 14 days) a dengue-endemic area. Clinical findings include nausea, vomiting, rash, aches and pains, a positive tourniquet test, leukopenia, or any warning sign.
4 days ago · 3. Surveillance data are reported by county of residence, not the location (county or state) of exposure. 4. There is a lag in case reporting to CDC and states and territories may publish surveillance data on different schedules than CDC. Find maps and data for dengue cases reported to ArboNET in the current year.
5 days ago · In the Region of the Americas, between epidemiological week (EW) 1 and EW 52 of 2021, a total of 1,430,922 cases of arboviral disease were reported. Of those, 1,269,271 ( 88.7 % ) were dengue cases, 138,399 ( 9.7 % ) chikungunya cases, and 23,252 ( 1.6 % ) were Zika cases. Country specific data on case counts and completeness can be found at ...
1 day ago · This is in stark contrast to the mapping profile of the 24–29 nt viral small RNA reads, which were five to tenfold higher in the genome sense (RNA 1, 9.32 ± 3.82 sense: 1 antisense and RNA 2, 5.56 ± 3.69 sense: 1 antisense), suggesting that these reads are more likely to have derived from the genomic ANV RNA (Figure 2d).
4 days ago · In a November 2019 study, QDENGA demonstrated protection against virologically confirmed dengue in children ages 4 to 16. The vaccine efficacy (VE) was 80.2% in the 12 months after the second vaccine dose, administered three months after the 1st dose. On July 13, 2020, the long-term Safety and immunogenicity of a tetravalent dengue vaccine ...
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5 days ago · Background: The 4 serotypes of dengue virus (DENV1,2,3,4) can each cause potentially deadly dengue disease, and are spreading globally from tropical and subtropical areas to more temperate ones. Nepal provides a microcosm of this global phenomenon, having met each of these grim benchmarks. To better understand DENV transmission dynamics and spread into new areas, we chose to study dengue in ...
