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4 days ago · How does transdermal nitroglycerin work (mechanism of action)? Transdermal nitroglycerin relaxes the blood vessels and increases oxygen and blood supply to the heart.
5 days ago · Jason Hawkes, MD, MS, medical dermatologist in Sacramento, California presented an in-depth overview on the mechanism of action (MOA) of Janus Kinase (JAK) inhibitors, a class of small molecules used to treat various inflammatory and autoimmune conditions.
2 days ago · Despite their high metabolic demands, neurons rely on ATP synthesis as needed. Yu et al. demonstrate that O-GlcNAcylation, a post-translational modification responsive to glucose flux, rapidly adjusts to neuronal activity, boosting mitochondrial plasticity and bioenergetics, thus coupling ATP synthesis rates to fuel availability for meeting energy demands.
3 days ago · Sublingual nitroglycerin has an onset of action of 2 to 3 minutes and is absorbed quickly because the area under the tongue is highly vascular. Intravenous nitroglycerin is quickly absorbed in the blood, and it has an onset of action of 1 to 2 minutes. Transdermal nitroglycerin has an onset of action of 30 to 60 minutes.
3 days ago · Note: the average corrected count-rate during the five control measurements was considered to be 100% in the individual patient. The arrow indicates the time at which nitroglycerin or sugar pills were given. Credit: this research was originally published in Ref. [10].
1 day ago · Rationale Alzheimer’s disease (AD), an age-dependent devastating neuropsychiatric disorder, is a leading cause of learning, memory and intellectual disabilities. Current therapeutic approaches for the amelioration of the anomalies of AD are not effective. Objective: In the present study, the molecular mechanisms underlying sporadic AD (sAD), the memory related behavioral analysis and ...
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3 days ago · Nitric oxide (NO) signaling, when it goes astray, is thought to contribute to migraine, but investigators are still working to understand the extent of its involvement and to uncover the pathophysiological mechanisms at play.
