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21 hours ago · The NeoSep1 trial will evaluate new combinations of existing antibiotics and compare them to treatment regimens that are currently used in newborn babies with suspected neonatal sepsis. 3 million babies affected every year. Neonatal sepsis, a life-threatening infection, affects up to 3 million babies a year globally.
1 day ago · We identified 1209 eligible sepsis huddles among 604 infants. There were 111 culture-confirmed LOI episodes (9% of all huddles). Twelve clinical signs of infection poorly distinguished infants with and without LOI, with sensitivity for each ranging from 2 to 36% and AUROC ranging 0.49-0.53.
5 days ago · A large prospective study was available on treatment of IEMs and optimal antibiotic therapy for the infected neonate. A well-researched literature review resulting in national guidelines was available regarding screening for congenital heart disease and treatment of neonatal sepsis.
2 days ago · Neonatal sepsis. In common clinical usage, neonatal sepsis refers to a bacterial blood stream infection in the first month of life, such as meningitis, pneumonia, pyelonephritis, or gastroenteritis, but neonatal sepsis also may be due to infection with fungi, viruses, or parasites.
2 days ago · Objective To assess the impact of publication of UK National Institute for Health and Care Excellence (NICE) guidelines on the prevention and treatment of early-onset infections (EOIs) in neonates (clinical guideline 149 (CG149), published in 2012, and its 2021 update (NG195) on antibiotic use in very preterm infants. Design Interrupted time series analysis using data from the National ...
21 hours ago · GBS infection can present with acute and sometimes fulminant pneumonia and sepsis or, alternatively, a more indolent later-onset bacteremia and meningitis . For incompletely understood reasons, serious GBS infections occur primarily in newborns, then remain quite rare in older infants, children, and healthy adults, with the exception of the ...
1 day ago · A total of 206 different antemortem clinical diagnoses were recorded. The most common clinical diagnosis among the enrolled cases was early onset neonatal sepsis (30/206, 14.6%), followed by perinatal asphyxia (24/206, 11.7%) and preterm baby (23/206, 11.1%) (Table 2). Other common diagnoses included low birth weight (21/206,10.2%) and ...
