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5 days ago · In summary, this study advances our fundamental understanding of the purine synthesis pathways in tissues and cancer and may inform us on designing rational strategies for targeting the de novo and salvage pathways to eradicate tumor growth and overcome resistance and metabolic adaptation to chemotherapy.
5 days ago · The synthesis of thermodynamically disfavoured substituted six-membered rings provides a notable challenge compared with that of the thermodynamically stable stereoisomer counterparts.
1 day ago · Although progress has been made in enantioselective hydroboration of di- and trisubstituted alkenes over the past decades, enantioselective hydroboration of tetrasubstituted alkenes with high diastereo- and enantioselectivities continues as an unmet challenge since the 1950s due to its extremely low reactivity and the difficulties to simultaneously control the regio- and stereoselectivity of a ...
5 days ago · Thiourea and its derivatives have become a significant focal point within the organic synthesis field, garnering attention for their diverse biological applications, including antibacterial, antioxidant, anticancer, anti-inflammatory, anti-Alzheimer, antituberculosis and antimalarial properties. My objective is to present a comprehensive and easily understandable analysis of recent ...
5 days ago · Molecular studies have shown that the synthesis of AFs is regulated by a complex cascade of transcriptional and post-transcriptional processes [19]. The biosynthesis of AFs involves a series of enzymatic and biotransformation reactions, as shown in Figure3. The pathway is initiated by acetyl-CoA and malonyl-CoA to form hexyl-CoA, which is then
5 days ago · The PCCB gene is located on chromosome 3q22.3 and is composed of 17 exons that generate two alternatively spliced mRNAs encoding proteins of 539 amino acids (isoform 1) and 559 amino acids (isoform 2). Mutations in either the PCCA gene or the PCCB gene result in the organic acidemia known as propionic acidemia.
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5 days ago · Chemometric analysis was used to analyze the differential components. Metabolic analysis and Kyoto encyclopedia of genes and genomes (KEGG) enrichment were utilized to explore the synthesis pathways of different components. Result: A total of 83 volatile and 79 non-volatile components were identified in Ephedra species.
