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23 hours ago · This paper presents a virus-like lipid nanoparticle decorated with spike proteins capable of carrying antigens, including mRNA and proteins, for vaccination against SARS-CoV-2 variants.
4 days ago · The viral titer, which is the amount of infectious virus, has been evaluated as one of the indexes of the drug efficacy of baloxavir marboxil for influenza virus 23, 24 and ensitrelvir for SARS-CoV-2. 25-27 It is important to know about the dynamics of the viral titer because this provides much useful information for understanding the virus ...
4 days ago · SARS-CoV-2 articles from across Nature Portfolio. SARS-CoV-2 is a positive-sense single-stranded RNA virus. It is contagious in humans and is the cause of the coronavirus disease 2019...
5 days ago · The spike protein determines the host-range specificity of coronaviruses. In particular, the Receptor-Binding Motif in the spike protein from SARS-CoV-2 contains the amino acids involved in molecular recognition of the host Angiotensin Converting Enzyme 2. Therefore, to understand how SARS-CoV-2 acquired its capacity to infect humans it is necessary to reconstruct the evolution of this ...
4 days ago · Both the hairpin and the pseudoknot structure have been shown to be critical for replication of the mouse hepatitis virus MHV—a model Betacoronavirus . In SARS-CoV-2, both structures have been detected by structural probing in vivo , but were not yet functionally interrogated. Likewise, the function of the apical part of SL1 containing the ...
4 days ago · Summary: Researchers have produced a high-resolution crystal structure of an enzyme essential to the survival of SARS-CoV-2, the virus that causes COVID-19. The discovery could lead to the...
3 days ago · The spike protein of the coronavirus, or SARS-CoV-2, binds to ACE2, a receptor on the host cells, which allows the virus to enter the cells and infect it. Binding is the first step for infection, and several mutations in previous variants of concern have been shown to be important for increasing the spike's binding to human ACE2.
