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3 days ago · Sepsis is a life-threatening syndrome caused by a dysregulated immune response. A large number of adaptor proteins have been found to play a pivotal role in sepsis via protein-protein interactions, thus participating in inflammatory cascades, leading to the generation of numerous inflammatory cytokines, as well as oxidative stress and regulated ...
3 days ago · Purpose Sepsis is a global public health burden. The sequential organ failure assessment (SOFA) is the most commonly used scoring system for diagnosing sepsis and assessing severity. Due to the widespread use of endotracheal intubation and sedative medications in sepsis, the accuracy of the Glasgow Coma Score (GCS) is the lowest in SOFA. We designed this multicenter, cross-sectional study to ...
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4 days ago · INTRODUCTION Sepsis constitutes a complex, life-threatening condition characterized by organ dysfunction and stems from a dysregulated host response to infection.1Data from 2020 reveal approximately 48.9 million sepsis cases globally, causing 11 million fatalities which represent 19.7% of worldwide deaths.2Recognizing its gravity, the World Hea...
2 days ago · It gives information on sepsis epidemiology, top tips for sepsis aware consultations and Sepsis leads, and clinical scenarios. The booklet is aimed to be used alongside e-learning and presentations to share sepsis learning across practices.
3 days ago · Is there a role for imaging in sepsis? Who needs to go to the ICU and who can be discharged? Table of Contents. Abstract. Case Presentations. Introduction. Definitions and Terminology. Critical Appraisal of the Literature. Epidemiology. Etiology and Pathophysiology. Differential Diagnosis. Prehospital Care. Emergency Department Evaluation. History.
4 days ago · Sepsis-associated acute kidney injury (SA-AKI) is a key contributor to the life threatening sequalae of sepsis. Mechanistically, SA-AKI is a consequence of unabated myeloid cell activation and oxidative stress that induces tubular injury. Iron mediates inflammatory pathways directly and through regulating the expression of ferritin, an iron storage protein comprised of ferritin light (FtL) and ...
15 hours ago · Feature papers represent the most advanced research with significant potential for high impact in the field. A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications.
