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Can hydrocortisone and thiamine treat severe sepsis and septic shock?
Does empiric combination antibiotic therapy improve outcome against sepsis due to Gram-negative bacteria?
Are myeloid-derived suppressor cells associated with chronic immune suppression after severe sepsis/septic shock?
3 days ago · Marik PE, Khangoora V, Rivera R, et al. Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock. Chest. 2017;151(6):1229-1238. (Before-after; 94 patients) Hotchkiss RS, Monneret G, Payen D. Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach.
5 days ago · Regulation of DC’s RCD can serve as a possible therapeutic focus for the treatment of sepsis. Throughout time, numerous tactics have been devised and effectively implemented to improve abnormal immune response during sepsis progression, including modifying the functions of DCs and inhibiting DC cell death.
5 days ago · Abstract Background Sepsis is a life-threatening disorder with no definitive cure. Preclinical studies suggest that extracellular vesicles derived from mesenchymal stromal cells (EV-MSCs) can mitigate inflammatory conditions, potentially leading to increased survival and reduced organ dysfunction during sepsis. Our aim to conduct this systematic review and meta-analysis is assessing the EV ...
5 days ago · A clinical trial supported by the National Institutes of Health (NIH) has found that intravenous acetaminophen reduced sepsis patients’ risk of having organ injury or developing acute respiratory distress syndrome (ARDS), a serious condition that allows fluid to leak into the lungs.
5 days ago · Current treatment options for sepsis include antibiotic therapy, surgery of damaged tissue and providing organ support according to the 2021 Surviving Sepsis Campaign (SSC) guidelines . European Union (EU) funded research (ImmunoSep) aims to restore the immune function in sepsis patients using personalised immunotherapy and a next-generation ...
5 days ago · Previous studies have indicated an association between sepsis and various ICU morbidities, including upper gastrointestinal bleeding (UGIB). However, the extent of this relationship and its implications in ICU settings remain inadequately quantified. This study aims to elucidate the association between sepsis and the risk of UGIB in ICU patients.
5 days ago · In 2017, VCU and six other hospitals completed a four-year trial using vitamin C to treat sepsis, a body-wide inflammation as a response to infection, and acute respiratory failure.
