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3 days ago · Morphine, a natural opioid found in opium, triggers synaptic plasticity and alters neuronal function in the ventral tegmental area (VTA) and nucleus accumbens (NAc), two key structures of the DA ...
1 day ago · Samatha Yohn, PhD, of Karuna Therapeutics and colleagues explain in a review 3 that activation of M1 receptors on cholinergic cortical inhibitory interneurons reduces excitatory tone of dopamine circuitry in the ventral tegmental area (VTA), and that M4 receptor activation leads to reduced dopamine cell firing in both the VTA and nucleus ...
2 days ago · Opioids stimulate μ-opioid receptors (μORs) in the ventral tegmental area (VTA) to enhance mesolimbic dopamine transmission. This action is thought to play a crucial role in opioid reward. μORs located outside the mesolimbic system also contribute to the addiction-related actions of opioids, but relatively little is known about these ...
2 days ago · As part of the reward pathway, dopamine is manufactured in nerve cell bodies located within the ventral tegmental area (VTA) and is released in the nucleus accumbens and the prefrontal cortex. The motor functions of dopamine are linked to a separate pathway, with cell bodies in the substantia nigra that manufacture and release dopamine into the ...
1 day ago · 5. First Love is Addictive. Psychologists at the University of Utah have found that the caudate nucleus and the ventral tegmental area (VTA) are the two brain regions associated with romantic love ...
5 days ago · The brain's reward system, involving structures such as the nucleus accumbens and the ventral tegmental area, plays a key role in motivating behavior by releasing dopamine, a neurotransmitter associated with pleasure and reward.
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4 days ago · These structures comprise the nucleus accumbens (NAc), ventral tegmental area (VTA), and PFC, all of which exhibit abnormalities in these disorders (Laviolette, 2021). Numerous neuropsychiatric disorders have etiological roots that may be traced back to neurodevelopmental processes, often manifesting at critical times of brain development in ...
