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5 days ago · These T cells appeared to develop their broad repertoires due to a combination of vaccination and breakthrough infection. COVID-19 vaccines taught the T cells to recognize a key part of SARS-CoV-2 called the “Spike” protein. Meanwhile, SARS-CoV-2 infection prompted T cells to recognize Spike, as well as several other viral proteins.
5 days ago · This study offers a structural insight into spike protein structural features which promote success in coronaviruses that infect bats and civets, and helps us to better understand what drives the success of these viruses in such a broad host range.
5 days ago · Anti-SARS-CoV-2 spike protein IgG antibody titers and the neutralizing activity titers against rBA.5 S-GFP virus in healthy controls and KTXRs after a third vaccine dose and bivalent omicron ...
5 days ago · The N protein preferentially favours action through TGF-β2, whose secretion is induced through TLR4-ROS action. TGF-β2 stimulates MRTF-A and MRTF-B nuclear translocation and strongly regulates EndMT. In contrast, the Spike protein stimulates TGF-β1 secretion as a result of ACE2 downregulation.
2 days ago · The viral spike (S) protein and its cognate receptor-binding domain (RBD), which initiate viral entry and play a critical role in virus pathogenesis, are important therapeutic targets. This review describes pathogenic human CoVs, including viral structures and proteins, and S protein-mediated viral entry process.
2 days ago · The vaccine is designed to target both the spike protein of the SARS‑CoV‑2 virus, and viral proteins that may be less prone to genetic variation, to provide greater protection against SARS‑CoV‑2 variants.
2 days ago · The SARS-CoV-2 spike protein consists of S1 and S2 proteins, which function in receptor recognition and mediate membrane fusion 4, 5. Cleavage of S1/S2 by proteases promotes binding of the...
