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19 hours ago · Sepsis is a severe condition that arises when the body’s response to an infection injures its own tissues and organs. It can develop in a very short timeframe – usually hours, if untreated.
5 days ago · Sepsis, systemic inflammatory condition that occurs as a complication of infection and in severe cases may be associated with acute and life-threatening organ dysfunction. Sepsis is a common cause of illness and mortality in hospitals. Learn more about the causes, symptoms, and treatment of sepsis.
- Kara Rogers
3 days ago · Microbial factors. Bacterial virulence factors, such as glycocalyx and various adhesins, allow colonization, immune evasion, and establishment of disease in the host. Sepsis caused by gram-negative bacteria is thought to be largely due to a response by the host to the lipid A component of lipopolysaccharide, also called endotoxin.
5 days ago · Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, commonly associated with nosocomial transmission. Gram-negative bacterial species are particularly problematic due to the release of the lipopolysaccharide toxins upon cell death. The lipopolysaccharide toxin of E. coli has a greater immunogenic potential than that of other Gram-negative ...
5 days ago · Approximately 24% of sepsis cases with organ dysfunction are acquired in the ICU, with ca. 49% being acquired in hospitals [41]. Studies have shown that 50% of sepsis-induced mortality is hospital-acquired sepsis (HAS), with the ICU admittance and AMR species contributing to disease severity and fatality [12].
5 days ago · The sepsis-induced derangements in microbial balance can themselves have a profound influence on immune function and cause harm to the host (Fig. 3) [89, 157]. Change in the host’s gut microbiome is bidirectionally linked to the CNS through vagal afferents, immune, and HPA axis modulation, and the CNS in turn can modulate the gut and enteric ...
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4 days ago · Sepsis is among the most costly and deadly conditions for hospitalized patients, and only a minority of patients with sepsis receive guideline-adherent care. In theory, government regulations like these would incentivize hospital-level quality improvement efforts leading to improved performance and increased survival for patients with sepsis.
