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3 days ago · Different candidates for post-exposure prophylaxis (PEP; ie, vaccines, antivirals, and monoclonal antibodies) each have their specific benefits and limitations, which we discuss in this Viewpoint. Approved monoclonal antibodies have been found to reduce mortality in people with Ebola virus disease.
4 days ago · The endemic nature of the Ebola virus disease in Africa underscores the need for prophylactic and therapeutic drugs that are affordable and easy to administer. Through a phenotypic screening employing viral pseudotypes and our in-house chemical library, we identified a promising hit featuring a thiophene scaffold, exhibiting antiviral activity in the micromolar range. Following up on this ...
1 day ago · Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins are expressed on the surface of infected erythrocytes, mediating parasite sequestration in the vasculature. PfEMP1 is a major target of protective antibodies, but the features of the antibody response are poorly defined. Methods In Malawian children with cerebral or uncomplicated malaria, we characterized the ...
4 days ago · Clinical Manifestation Severe headache, weakness, muscle pain, vomiting, diarrhea, abdominal pain, or unexplained hemorrhage are the symptoms that raise suspicion for Ebola virus disease. Symptoms may appear anywhere from 2 to 21 days after contact with the virus, with an average of 8 to 10 days. “Dry” symptoms.
1 day ago · Biodefense Headlines – 12 September 2024. This week’s selections include failures in responding to the mpox public health emergency, security screening considerations for gene synthesis providers, a human H5 flu case in Missouri not directly linked to animal contact, and a pretend Ebola alert gets an IT department in hot water.
4 days ago · Layered defense. The immune system protects its host from infection with layered defenses of increasing specificity. Physical barriers prevent pathogens such as bacteria and viruses from entering the organism. [1] . If a pathogen breaches these barriers, the innate immune system provides an immediate, but non-specific response.
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How do bacteria protect themselves from viral pathogens?
How do bacteria protect themselves from viral pathogens?
1 day ago · Acute inflammation may be regarded as the first line of defense against injury and is characterized by changes in the microcirculation: exudation of fluid and emigration of leukocytes from blood vessels to the area of injury.
