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Eric Sebastian Fischer, Ph.D. Professor of Biological Chemistry and Molecular Pharmacology. 617-632-6488. Email. Fischer lab website. Bio. Contact. Publications. We combine structural biology, cell biology and biochemical reconstitutions to address the molecular workings of multi-protein ubiquitin ligase complexes.
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496. 2016. The molecular basis of CRL4 DDB2/CSA ubiquitin ligase architecture, targeting, and activation. ES Fischer, A Scrima, K Böhm, S Matsumoto, GM Lingaraju, M Faty, ... Cell 147 (5), 1024-1039. , 2011. 453. 2011. Plasticity in binding confers selectivity in ligand-induced protein degradation.
Eric Fischer. Associate Professor of BCMP. Summary. Description. We combine structural biology, cell biology and biochemical reconstitutions to address the mechanistic principles that govern signaling through the ubiquitin proteasome system. We seek to leverage our molecular understanding to propose and test new avenues of therapeutic intervention.
Eric Fischer, PhD. No Ratings Available - Why Not? MAKE AN APPOINTMENT. Contact Information. Office Phone Number. 617-582-9281. On This Page. Research. View Dr. Fischer’s Research. Research Departments. Cancer Biology. Research Website. http://fischerlab.dana-farber.org/ Discovery and Insights.
HOME / PEOPLE / Eric Fischer. Associate Professor of Biological Chemistry and Molecular Pharmacology. The Ubiquitin Proteasome System (UPS) is involved in virtually any cellular process and frequently implicated in human pathologies. Ubiquitin, through the action of a three-enzyme cascade (E1, E2 and E3), becomes attached to substrate proteins.
Aug 18, 2018 · Nature Chemical Biology. 2023 Sep. Proteomics-Based Discovery of First-in-Class Chemical Probes for Programmed Cell Death Protein 2 (PDCD2) Ji W, Byun WS, Lu W, Zhu X, Donovan KA, Dwyer BG, Che J, Yuan L, Abulaiti X, Corsello SM, Fischer ES, Zhang T, Gray NS. Angewandte Chemie International Edition. 2023 Oct.
