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Isaac Wayne (1772 – October 25, 1852) was an American politician from Pennsylvania who served as a Federalist Party member of the U.S. House of Representatives for Pennsylvania's 4th congressional district from 1823 to 1825. He previously served as a member of the Pennsylvania House of Representatives from 1799 to 1801 and in 1806, and served as a member of the Pennsylvania State Senate from 1807 to 1810. Wikipedia