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What causes a paroxysmal spell?
What is a paroxysmal spell?
What are the different types of Interictal discharges?
Jul 17, 2023 · Paroxysmal spells are non-epileptic, paroxysmal events that may mimic epileptic seizures but are not associated with rhythmic discharges of cortical neurons typical of seizures. They clinically manifest as a transient loss of consciousness, often occurring suddenly, with or without a prodrome.
- Oren J. Mechanic, Shamai A. Grossman
- 2023/07/17
- Harvard Medical School/BIDMC, HVD Med Sch
However, paroxysmal runs of fast activity can be epileptiform, and are most commonly seen in patients with generalized epilepsy, Lennox-Gastaut Syndrome, and tonic seizures. Paroxysmal fast activity can be localized, as in the example below, or generalized.
Dec 31, 2022 · The underlying cellular pathophysiology of focal spikes is believed to be the paroxysmal depolarization shift (PDS). Several decades of studies using cortical application of penicillin or other...
A paroxysmal depolarizing shift ( PDS) or depolarizing shift is a hallmark of cellular manifestation of epilepsy. Little is known about the initiation, propagation and termination of PDS. Previously, electrophysiological studies have provided the evidence that there is a Ca 2+ mediated depolarization, which causes voltage gated Na + channels to ...
This sequence is called the paroxysmal depolarizing shift. ( Slide 23 ) The bursting activity resulting from the relatively prolonged depolarization of the neuronal membrane is due to influx of extracellular Ca ++ , which leads to the opening of voltage-dependent Na + channels, influx of Na + , and generation of repetitive action potentials.
- Edward B Bromfield, José E Cavazos, Joseph I Sirven
- 2006
- 2006
Aug 25, 2023 · A nonspecific sign of disturbed brain function. Paroxysmal discharge. A general term used to describe any pattern of electrical activity which begins suddenly and stands out from the background electrical activity of the brain (e.g., spikes, sharp waves. , etc.) An epileptiform discharge. Sharp wave.
Interictal epileptic discharges (IEDs), including sharp waves, spikes, and spike–wave complexes, are paroxysmal waveforms seen in the electroencephalogram (EEG) of people with epilepsy. Early EEG investigations studied the diagnostic yield and localizing value of IEDs in sleep.
