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Based on a true story, this film focuses on the quest to discover the building blocks of DNA. American scientist Jim Watson (Jeff Goldblum) joins forces with his English counterpart, Francis Crick (Tim Pigott-Smith), and together they strive to outdo their brilliant contemporaries as they make progress towards unlocking DNA's double-helix structure. The movie captures the personalities and tenacious attitudes of the researchers, particularly Watson and his considerable eccentricities.