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In a quintet of stories, the murder of a young runaway (Brittany Murphy) connects a group of unrelated women. Lonely Arden (Toni Collette) discovers the body; Leah (Rose Byrne), a forensics student, thinks the victim may be her long-missing sister. Melora (Marcia Gay Harden) arrives in Los Angeles to piece together the last days of her daughter's life, while Ruth (Mary Beth Hurt) makes a disturbing discovery in the storage facility she and her husband manage.