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p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation.
The p53 gene like the Rb gene, is a tumor suppressor gene, i.e., its activity stops the formation of tumors. If a person inherits only one functional copy of the p53 gene from their parents, they are predisposed to cancer and usually develop several independent tumors in a variety of tissues in early adulthood. This condition is rare, and is known as Li-Fraumeni syndrome.
The p53 pathway is a complex cellular stress response network with multiple diverse inputs and downstream outputs relevant to its role as a tumor suppressor pathway. While inroads have been made in understanding the biology and signaling in the p53 pathway, the p53 family, transcriptional readouts, and effects of an array of mutants, the ...
Mar 1, 2023 · The p53 pathway. p53 is a transcription factor that is distributed in the nucleus and cytoplasm, binds specifically to DNA, and regulates a diversity of genes. 25,26 Under normal conditions ...
Mar 1, 2019 · p53 was initially identified in complex with the simian virus 40 T antigen in transformed rodent cells 1,2 and was first recognized as a tumour suppressor in 1989 (refs 3,4); subsequently, p53 has ...
Feb 23, 2022 · The road to p53 discovery. P53 is found to be mutated in over 50% of human cancers and the remaining of the 100% involve biological inactivation of its pathway including MDM2 amplification, loss of p14ARF and mutations in activating kinases like ATM and Chk2 [].Loss of p53 pathway function gives cancer cells a survival advantage to bypass the resolution of oncogenic signals and DNA damage to ...
p53 is an important tumour-suppressor protein that is altered in most cancers. p53 activates various responses, including cell-cycle arrest and apoptosis. Each of these appears to contribute to ...
Mar 28, 2024 · Indeed, just a few years ago, the TP53 gene, encoding p53, was voted the most “popular” human gene. Now, on the 50 th anniversary of Cell, we reflect on what we have learned about p53 after all this attention. We describe here the paradox of how, depending on its mutational status in cancer, p53 can be both a tumor suppressor and an ...
Apr 3, 2024 · GeneCards Summary for TP53 Gene. TP53 (Tumor Protein P53) is a Protein Coding gene. Diseases associated with TP53 include Li-Fraumeni Syndrome and Papilloma Of Choroid Plexus . Among its related pathways are MyD88 dependent cascade initiated on endosome and Regulation of activated PAK-2p34 by proteasome mediated degradation .
Oct 25, 2023 · The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and growth of tumors. A gene that has been coined "the guardian of the genome," when inactivated, it can also play a role in the persistence, growth ...
