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- Season 6 overviewApr 30-Sep 17, 201821 episodesSeason 6 episodes1. An Infinite Capacity for Taking Pains Apr 30, 2018
- Holmes struggles with a medical diagnosis that threatens his career and sobriety.
- 2. Once You've Ruled Out God May 7, 2018
- Watson's estranged father dies; Holmes and Watson hunt for a stolen plutonium shipment.
- 3. Pushing Buttons May 14, 2018
- The duo investigates a case in which the victim was killed during a Revolutionary War re-enactment.
- 4. Our Time Is Up May 21, 2018
- Watson and Holmes investigate the murder of Watson's former psychologist.
- 5. Bits and Pieces May 28, 2018
- Holmes and Watson retrace Holmes' steps after Holmes finds himself in possession of a severed head.
- 6. Give Me the Finger Jun 4, 2018
- Holmes and Watson investigate the murder of a former Japanese crime syndicate gang member.
- 7. Sober Companions Jun 11, 2018
- Holmes and Watson are on the hunt for a serial killer after a murder rocks their inner circle.
- 8. Sand Trap Jun 18, 2018
- Holmes and Watson search for the killer of a woman found encased in cement.
- 9. Nobody Lives Forever Jun 25, 2018
- A former sobriety sponsor asks Holmes for help with an illegal endeavor to save his brother.
- 10. The Adventure of the Ersatz Sobekneferu Jul 2, 2018
- Sherlock and his father try to repair their relationship upon learning of a death in the family.
- 11. You've Come a Long Way, Baby Jul 16, 2018
- Holmes engages an old foe to protect his father after he learns Morland is in danger.
- 12. Meet Your Maker Jul 23, 2018
- Detective Bell considers leaving the NYPD after he is recommended for a career opportunity.
- 13. Breathe Jul 30, 2018
- Holmes and Watson investigate the poisoning of a relocation expert who had a secret career.
- 14. Through the Fog Aug 6, 2018
- Holmes and Watson race to help Bell when he becomes a victim of bioterrorism at the precinct.
- 15. How to Get a Head Aug 12, 2018
- The murder of a religion professor puts the duo on a hunt for a killer connected to the occult.
- 16. Uncanny Valley of the Dolls Aug 13, 2018
- The murder of a robotics engineer may be connected to his groundbreaking research in teleportation.
- 17. The Worms Crawl in, the Worms Crawl Out. Aug 20, 2018
- The duo investigates when a zoologist is murdered; Holmes' identity is stolen.
- 18. The Visions of Norman P. Horowitz Aug 27, 2018
- A killer chooses victims based on the predictions of a man who claimed to foresee future deaths.
- 19. The Geek Interpreter Sep 3, 2018
- Holmes and Watson race to locate a missing woman; Holmes' friend becomes the prime suspect.
- 20. Fit to Be Tied Sep 10, 2018
- Holmes and Watson's deadly conflict with Sherlock's former friend intensifies.
- 21. Whatever Remains, However Improbable Sep 17, 2018
- Holmes and Watson's murder investigation threatens to destroy their partnership.