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- Season 4 overviewSep 19, 1996-May 8, 199724 episodesSeason 4 episodes1. Murder by Friendly Fire Sep 19, 1996
- A veteran cop shoots another during a drug raid; Mark suspects murder.
- 2. Murder Can Be Contagious Sep 26, 1996
- Dr. Sloan and Jesse are exposed to a deadly chemical warfare virus.
- 3. Murder on Thin Ice Oct 3, 1996
- A man found dead at an ice-skating rink had attacked a world-class figure skater during competition.
- 4. X Marks the Murder Oct 10, 1996
- Mark and Steve track down a serial killer moments before Amanda is slain.
- 5. A Model Murder Oct 17, 1996
- Mark and Steve enter the world of modeling to track down a killer.
- 6. Murder Can Be Murder Oct 24, 1996
- Mark gets suspicious when a patient who died in the ER is cremated before an autopsy can be done.
- 7. An Explosive Murder Oct 31, 1996
- Mark is nearly killed by a bomb; Steve's protege goes under cover.
- 8. Murder by the Busload Nov 7, 1996
- Dr. Sloan discovers that a bus accident victim was actually murdered.
- 9. A Candidate for Murder Nov 14, 1996
- Mark suspects a political cover-up after a senator's daughter dies.
- 10. The ABCs of Murder Nov 21, 1996
- The drive-by killing of a high-school teacher seems to be gang-related; Mark has another theory.
- 11. Murder in the Family Dec 12, 1996
- Mark's estranged daughter comes home; then her abusive husband is found murdered.
- 12. In Defense of Murder Jan 9, 1997
- A respected pediatric nurse is a prime suspect in the murder of a madam.
- 13. A History of Murder Jan 16, 1997
- The bones of Dr. Sloan's mentor are found at a groundbreaking ceremony.
- 14. Murder Two, Part One Jan 30, 1997
- Mark asks Ben Matlock to help in a malpractice case that turns to murder.
- 15. Murder Two, Part Two Feb 6, 1997
- Two murders and a lot of money point Mark and Ben to the real killer.
- 16. Hard-Boiled Murder Feb 13, 1997
- Mark and his pal Joe Mannix (Mike Connors) team to solve a 25-year-old murder.
- 17. Murder, Country Style Feb 20, 1997
- A murdered country superstar may have been involved in a mother-daughter love triangle.
- 18. Delusions of Murder Feb 27, 1997
- Amanda's friend lies next to a corpse, holding the murder weapon.
- 19. Passion for Murder Apr 3, 1997
- A beautiful stalker targets the hospital's new chief of staff.
- 20. Blood Brothers Murder Apr 10, 1997
- Steve takes custody of a boy accused of murdering a gang leader.
- 22. Physician, Murder Thyself Apr 24, 1997
- When a prominent physician is murdered, his colleagues become suspects.
- 23. The Merry Widow Murder May 1, 1997
- A society woman and her younger lover plot to kill her husband and frame Mark.
- 24. Comedy Is Murder May 8, 1997
- An inept comedian targets his former partner, but his ex-wife gets killed.
- 25. The Murder of Mark Sloan May 8, 1997
- Released on a technicality, a convict tries to fulfill his threat to kill Mark.